Current and Recent Projects
Non-alcoholic fatty liver disease (NAFLD), chronic hepatitis B (HBV), and chronic hepatitis C infection are the leading causes of chronic liver disease and hepatocellular carcinoma in the US. NAFLD, comprising non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH) affects 30% of the adult population and at least 10% of children. NASH related liver transplantations are predicted to eclipse other indications over the next decade, and NASH has emerged as the dominant cause of hepatocellular carcinoma (HCC), the only cancer with rising incidence and third leading cause of cancer mortality.
- Facilitating Drug Development for the Prevention and Treatment of CMV Disease in Transplation Settings
Cytomegalovirus (CMV), a common herpes virus that remains latent under normal circumstances, can be reactivated and shed when the immune system is compromised. People who are immune-incompetent or immunocompromised, such as transplant patients, HIV/AIDS patients, and newborn babies, are at risk for severe and life-threatening infections involving fever, pancytopaenia, and inflammatory changes in multiple organs.
The Forum HIV Cure Research Project will convene a series of meetings to address the clinical trial and regulatory issues surrounding HIV cure research. Focusing on the ethical, regulatory and clinical factors of HIV cure research, the project will utilize the traditional Forum approach of engaging key stakeholders, including those from the FDA, NIH, academia, advocates, and industry.